The objective of the survey was to collect data on a wide range of household and individual welfare indicators–including wealth, livelihoods, unemployment, food insecurity, diet quality, health shocks, and coping strategies–in a country exceptionally hard hit by conflict, severe economic collapse, and several damaging waves of COVID-19. The respondents interviewed in the MHWS were purposely selected from a large phone database aimed at being representative at the region/state level and urban/rural level in Myanmar. A novel sampling strategy in combination with the development of household and population weights allows for estimates that are nationally, regionally, and urban/rural representative.