On the basis of case studies in Germany and France, this volume investigates how MNEs cope with technical, economic and institutional uncertainties by drawing upon the complementary strengths of organisational and regional networks in national and European contexts. The book links two theoretical debates which are currently still largely disconnected -- the debate on learning processes in MNEs and the debate on the regional bases of innovativeness and competitiveness -- answering the question of how the internationalisation of R&D is reconciled with regional competences.