Epigenetics and DNA Damage
Miriam Galvonas Jasiulionis
08/2022 · Translational Epigenetics Livro 33 · Academic Press
Livro eletrónico
336
Páginas
family_home
Elegível
info
reportAs classificações e as críticas não são validadas Saiba mais
Acerca deste livro eletrónico
Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research. - Offers a thorough foundation in epigenetics and DNA damage research, as well as informed discussion of evolving research trends, disease findings, and early therapeutics - Features chapter contributions from leading international contributors - Empowers scientists to apply protocols in DNA damage and epigenetic alteration analysis and experimatation in their own research
Acerca do autor
Dr. Miriam Galvonas Jasiulionis is a Professor at the Department of Pharmacology, in the Laboratory of Ontogeny and Epigenetics, at the Universidade Federal de São Paulo, Brazil. Her lab has investigated the role of epigenetic alterations in the relationship between sustained stressful conditions and malignant transformation, especially in melanocytes, to contribute to better comprehension of mechanisms involved in melanoma genesis and open avenues to develop novel therapeutic approaches. Dr. Jasiulionis has published widely in such peer reviewed journals as Clinical Epigenetics, Molecular Oncology, Frontiers in Immunology, Oncotarget, Epigenetics, and Neoplasia.
Classifique este livro eletrónico
Dê-nos a sua opinião.
Informações de leitura
Smartphones e tablets
Instale a app Google Play Livros para Android e iPad/iPhone. A aplicação é sincronizada automaticamente com a sua conta e permite-lhe ler online ou offline, onde quer que esteja.
Portáteis e computadores
Pode ouvir audiolivros comprados no Google Play através do navegador de Internet do seu computador.
eReaders e outros dispositivos
Para ler em dispositivos e-ink, como e-readers Kobo, tem de transferir um ficheiro e movê-lo para o seu dispositivo. Siga as instruções detalhadas do Centro de Ajuda para transferir os ficheiros para os e-readers suportados.
